Eminyakeni yamuva, ukwanda komdlavuza webele, okuwusongo olukhulu empilweni nempilo yabesifazane. Nakuba ingelashwa ngokusikwa ngokuhlinzwa, ukubikezelwa kwesikhathi eside kweziguli kusengakagculisi ngenxa yezehlakalo eziphezulu zokuphindaphinda kwangemva kokuhlinzwa kanye ne-metastasis. Njengamanje, i-postoperative adjuvant chemotherapy isetshenziswa kakhulu ukunciphisa ukuphindaphinda kanye ne-metastasis, kodwa izinkinga nemiphumela emibi kuvame ukuhambisana nale nqubo. Ngakho-ke, kuyaphuthuma ukunciphisa imiphumela emibi ye-adjuvant chemotherapy futhi kuthuthukiswe ukubikezelwa okubi kweziguli.

Ngenxa yalokhu, ithimba labacwaningi laseNingizimu-ntshonalanga ye-Jiaotong University liphakamise ukwakheka kwe-hierarchical okufakekayo kwama-ultrafine nanofibers, anamandla okulawula ukukhishwa kwezidakamizwa futhi abonise imiphumela emihle kakhulu yokwelapha ku-chemotherapy yendawo yangemva kokuhlinzwa yomdlavuza webele.

Ama-nanofiber alungiswe yi-coaxial electrostatic spinning ne-polylactic acid (PLA) elayishwe i-dithiolam (DSF) ne-polyethylene glycol (PEG) elayishwe nge-DOX · HCl ekamelweni. Ngemva kokufakelwa, i-DOX · HCl ku-lumen yakhululwa ngokushesha emithanjeni, iqeda amangqamuzana e-tumor asele futhi ivimbele ukuphindaphinda kwendawo yesimila. I-DSF ku-fibrous matrix idedelwa ngokuqhubekayo, ivimbele amaseli wesimila ukuthi angahlaseli izicubu ezizungezile futhi ngaleyo ndlela avimbele i-metastasis.

Ukubonakaliswa kwe-morphological of fibers

Imiphumela ibonisa ukuthi ukuhwamuka kwamanzi kusixazululo se-PEG kungakha imbobo enqubweni ye-electrospinning, futhi umthamo we-cavity mkhulu ngokwanele ukuhlanganisa i-DOX · HCl. Umthamo kanye nokuhlukaniswa kwamaChambers kungafinyelelwa ngokushintsha isisindo samangqamuzana e-PEG, futhi ubukhulu bamaChambers bunomthelela omkhulu ekukhululweni kwezinga le-DOX · I-HCl ehlanganiswe ku-Chambers.

Ukuziphatha kokukhishwa kwezidakamizwa

Abacwaningi basebenzise i-Maestro in vivo imaging system ukuze baqaphe ikhono le-fiber device's ukuvimbela ukuphindeka kwesimila kanye ne-metastasis, kanye nokuqhubeka nokuhlola ikhono lemishini yefayibha efakelwayo ukuvimbela ukuphindeka kwesimila kanye ne-metastasis ku-vivo. Kwatholakala ukuthi umthamo wesimila wedivayisi efakwe endaweni wawumncane kakhulu kunalowo wethumba elijovwe, ikakhulukazi lapho isisindo samangqamuzana e-PEG sasingu-1000, ivolumu yesimila yesimila esijovwe sasingaphansi kwe-1/80 yaleyo yesimila esijovwe, futhi iningi lamaseli e-tumor lalisesimweni esingandali.

Ukuhlaziywa kwe-vivo kokuvimbela ukuphindaphinda kwe-tumor kanye ne-metastasis