Ekwelapheni iziguli ezinesifo senhliziyo, izingxenye ezilimele noma ezivinjiwe zesimiso senhliziyo nemithambo yegazi ngezinye izikhathi zidinga ukushintshwa, kungaba ukufakelwa kwe-autologous noma ngezinto ezihambisana ne-biocompatible. Ukufakelwa kwe-autologous akudingi nje kuphela ukuthi isiguli singanikeza ingxenye enempilo esikhundleni, kodwa futhi ukuthi ukushintshwa ngeke kuthinte impilo evamile yesiguli, ngakho-ke izidingo ziphakeme kakhulu. Ezigulini eziningi ezinesifo senhliziyo, odokotela bavame ukusebenzisa imithambo yegazi yokwenziwa ukuze baqedele ukuhlinzwa.

Imithambo yegazi yokwenziwa yenziwa ngezinto ezihlukahlukene nezindlela. Muva nje, ithimba labacwaningi abavela ku-NC State kanye ne-CWRU bahlanganise umkhumbi wegazi wokwenziwa ngokuhlanganisa i-collagen ne-polylactic acid fibers.

Okusha ngalo mthambo wegazi wokwenziwa ukuthi:

(1) Izingxenye ze-collagen emicu ye-collagen zingandisa ukunamathela kwamangqamuzana okuqala izikhathi ezingu-10. Ngemuva kwenkathi ethile yesiko, inani lokuqoqwa kwamangqamuzana nokwanda liphindwe izikhathi ezingu-3.2 kunemithambo yegazi yokwenziwa eyenziwe nge-PLA fiber kuphela, enomphumela wokuqeda ngokushesha.

(2) I-polylactic acid fiber inganikeza amandla anele emishini nokuzinza kwesakhiwo, futhi idlale indima yengqalasizinda, ehambisana nokukhiqizwa kwesivinini esikhulu salo mkhumbi wegazi wokwenziwa, ukuze kuzuzwe ukuthuthukiswa kwezimboni.

(3) Imithambo yegazi yokwenziwa ehlanganisiwe ehlanganisiwe ibonise amandla amahle kakhulu okuphuka (1.89±0.43 MPa) namandla okugcina i-suture (10.86±0.49 N), kanye nezinga lokucindezela (3.98± 1.94% / 100 mmHg) laliqhathaniswa nalelo lemithambo yenhliziyo engaphansi kwe-8g ± 3% yomfutho wegazi ovamile (300%) omuhle (3.3%). ukuzivumelanisa nezimo.

(4) Isakhiwo sokuluka esiyindilinga sivumelana nezimo njengomthambo wenhliziyo wemvelo futhi singanwebeka futhi sinciphe.

Lolu hlobo lwesifo semithambo yokwenziwa alulona ukufakwa unomphela futhi lunganikeza ukwesekwa kokulungiswa kwemithambo yegazi esigabeni sokuqala sokufakelwa, okungagcina kucekelwe phansi futhi kuthathwe umzimba. Inkinga eyinhloko, iqembu elisazama ukuyinqoba, ukuthi umkhumbi unezimbotshana zesakhiwo ezivumela igazi ukuba liphume.

Umsebenzi weqembu unesihloko esithi "I-hybrid vascular graft ehlanganisa izici eziphakeme zemishini zemicu yokwenziwa kanye nokusebenza kwebhayoloji kwe-Collagen filaments," Ishicilelwe kokuthi Materials Science and Engineering: C.

Isixhumanisi sokuqala: https://doi.org/10.1016/j.msec.2020.111418